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植物次生代谢及抗病信号转导
漆小泉     研究员

1984年，华中农业大学获学士学位；

1990年，英国伯明翰大学获硕士学位；

1998年，荷兰瓦格宁根大学获博士学位；

1998-2005年，英国John Innes Center博士后；

2005-2006年，英国John Innes Center做Senior Research Associate；

2006年至今，中国科学院植物研究所植物代谢与抗病创新研究组组长；

任国际萜类代谢（Terpnet 2017）第13届执行委员会主席；国际细胞色素P450多样性及生物技术大会第13 - 15届（2020）学术委员会委员；中国植物学会第一届监事会监事，中国植物生理与分子生物学学会和中国生物物理学会代谢组学分会理事；担任Frontiers in Plant Science和植物学报杂志副主编及Plant Biotechnology Journal和Theoretical and Applied Genetics等编委。

迄今在Nature Communications、Theoretical and Applied Genetics、Nature Chemical Biology、Annual Review of Phytopathology、Proc. Natl. Acad. Sci. USA、Plant Cell、Molecular Plant等SCI期刊发表研究论文70余篇，被引用3400余次。出版《植物代谢组学—方法与应用》中英文专著各1部。获授权中国专利18项，申请国际专利（PCT）2项。

联系方式：010-62836671 E-mail：xqi@ibcas.ac.cn
  • 研究方向
  • 课题组成员

1. 植物代谢物的合成及其功能研究 

植物合成并积累种类繁多的代谢物。这些代谢物在植物的生长发育、环境适应中发挥着重要作用；一些特殊的代谢物是重要药物和人体必需的重要营养成分。我们以水稻、丹参等为主要研究材料，采用分子生物学以及包括代谢组学在内的分子系统生物分析方法系统地解析植物萜类及其它代谢物的生物合成途径及其调控机理，重点揭示代谢物和及其合成途径的生物学功能。

 

2. 植物代谢组学及其应用 

植物合成的代谢物有20万至100万种之多，且结构与理化性质差异很大，从而使植物的代谢组学研究更具挑战性。我们使用先进的分析仪器，结合现代组学和系统生物的数据分析手段，进行植物代谢物的定性和定量分析；探索代谢组学在揭示植物科学、农业生产和环境安全等领域的应用前景。 

3. 植物持久抗病性的分子机制研究 

作物的持久抗病性在农业生产中具有重要的应用价值，如，小麦条锈病在我国小麦主产区发病严重，危害小麦产量。然而小麦的基因组庞大、复杂，严重阻碍了其功能基因组学的研究。我们利用基因组较小、具有全基因组序列的二穗短柄草为模式植物，解析麦类作物与麦类锈菌的互作机制，为麦类作物的持久抗病品种培育和农业可持续发展提供理论依据。

 

  • 侯柄竹

    助理研究员
    bingzhuhou@163.com
    010-62836944

  • 董寰

    助理研究员
    donghuan@ibcas.ac.cn
    010-62836944

  • 张凡

    助理研究员

  • 宋波

    工程师
    song-bo178@163.com
    010-62836944

  • 张英春

    工程师
    zhangyingchun@ibcas.ac.cn
    010-62836949

  • 马爱民

    博士后
    lini.09@163.com
    010-62836944

  • 熊星辰

    博士生
    xcxiong2016@163.com

  • 刘波

    博士生
    1770182494@qq.com

  • 李翠

    博士生

  • 乔钰媛

    博士生
    qiaoyuyuan@ibcas.ac.cn

  • 马创新

    博士生
    539222956@qq.com
    010-62836944

  • 纪灏君

    直博生

  • 夏同

    硕士生

  • 宋照昀

    直博生
    songzhaoyun@ibcas.ac.cn

  • 姚淑君

    博士生

  • 赵广瀚

    硕士生

  • 王晨曦

    硕士生
    chenxiw506@163.com

  • 孟庆雨

    硕士生

研究论文
  • Qiao YY#, Hou BZ#, Qi XQ*. 2023. Biosynthesis and transport of pollen coat precursors in angiosperms. Nature Plants, https://doi.org/10.1038/s41477-023-01413-0
  • Ma Y, Cui GH*, Chen T, Ma XH, Wang RS, Jin BL, Yang J, Kang LP, Tang JF, Lai CJ, Wang YN, Zhao YJ, Shen Y, Zeng W, Peters R, Qi XQ*, Guo J*, Huang LQ*. 2021. Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza. Nature Communications, 21: 685
  • Lian XF#, Zhang XL#, Wang F,Wang XN, Xue ZY*, Qi XQ*. 2020. Characterization of a 2,3-oxidosqualene cyclase in the toosendanin biosynthetic pathway of Melia toosendan. Physiologia Plantarum, 170: 528-536
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  • Duan LX#, Ma AM#, Meng XB, Shen GA, Qi XQ*. 2020. QPMASS: A parallel peak alignment and quantification software for the analysis of large-scale gas chromatography-mass spectrometry (GC-MS)-based metabolomics datasets. Journal of Chromatography A, 1620: 460999 [下载]
  • Wang YJ，Subedi S, Viries H, Doornenbal P, Vels A, Hensel G, Kumlehn J, Johnston P, Wang YJ，Subedi S, Viries H, Doornenbal P, Vels A, Hensel G, Kumlehn J, Johnston P, Qi XQ，Blilou L, Niks RE, Krattinger S，Blilou L, Niks RE*, Krattinger S*. 2019. Orthologous receptor kinases quantitatively affect the host status of barley to leaf rust fungi. Nature Plants, 5:1129-1135[下载]
  • Zhang YC, Chi X, Feng LB, Wu XW, Qi XQ*. 2019. Improvement of multiplex semi-nested PCR system for screening of rare mutations by high-throughput sequencing. BioTechniques, doi:10.2144/btn-2019-0001
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  • Liu MY, Zhang CJ, Duan LX, Luan QQ, Li JL, Yang AG, Qi XQ*, Ren ZH*. 2019.  CsMYB60 is a key regulator of flavonols and proanthocyanidans that determine the colour of fruit spines in cucumber. Journal of Experimental Botany, 70: 69-84
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  • Xue ZY＃, Tan ZW＃, Huang AC, Zhou Y, Sun JC, Wang XN,Thimmappa RB, Stephenson MJ, Osbourn A, Qi XQ*. 2018. Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species. New Phytologist, 1076-1088 [下载]
  • Xue ZY＃, Xu X＃, Zhou Y＃, Wang XN, Zhang YC, Liu D, Zhao BB, Duan LX, Qi XQ*. 2018. Deficiency of a triterpene pathway results in humidity-sensitive genic male sterility in rice. Nature Communications, 9: 604 [下载]
  • Duan LX, Molnár I, Snyder J, Shen GA, Qi XQ*. 2016. Discrimination and quantification of true biological signals in LC-MS-based metabolomics analysis. Molecular Plant, 9: 1217-1220 [下载]
  • An TY, Cai YL, Zhao SZ, Zhou JH, Song B, Bux H, Qi XQ*. 2016. Brachypodium distachyonT-DNA insertion lines: a model pathosystem to study nonhost resistance to wheat stripe rust. Scientific Reports, 6: 25510 [下载]
  • Cui GH, Duan LX, Jin BL, Qian J, Xue ZY, Shen GA, Snyder J, Song JY, Chen SL, Huang LQ, Peters R, Qi XQ*. 2015. Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza bunge. Plant Physiology, 169: 1607-1618 [下载]
  • Niks R, Qi XQ, Marcel T*. 2015. Quantitative resistance to biotrophic filamentous plant pathogens: Concepts, misconceptions, and mechanisms. Annual Review of Phytopathology, 53: 445-470 [下载]
  • Xie LX, Tan ZW, Zhou Y, Xu RB, Feng LB, Xing YZ, Qi X*. 2014. Identification and fine-mapping of quantitative trait loci for seed vigor in germination and seedling establishment in rice. Journal of Integrative Plant Biology, 56: 749-759 [下载]
  • Shang Y, Ma YS, Zhou Y, Zhang HM, Duan LX, Chen HM, Zeng JG, Zhou Q, Wang SH, Gu WJ, Liu M, Ren JW, Gu XF, Zhang SP, Wang Y,Yasukawa K, Bouwmeester H, Qi XQ, Zhang ZH,Lucas W, Huang SW*. 2014. Biosynthesis, regulation, and domestication of bitterness in cucumber.Science, 346: 1084-1088 [下载]
  • Chi X, Zhang YC, Xue ZY, Feng LB, Liu HQ, Wang F, Qi XQ*. 2014. Discovery of rare mutations in extensively pooled DNA samples using multiple target enrichment. Plant Biotechnology Journal, 12: 709-717 [下载]
  • Snyder J, Qi XQ*. 2013. BIOSYNTHESIS metal matters. Nature Chemical Biology, 9: 295-296 [下载]
  • Cao XH, Zhou JH, Gong XP, Zhao GY, Jia JZ, Qi X*. 2012. Identification and validation of a major quantitative trait locus for slow-rusting resistance to stripe rust in wheat. Journal of Integrative Plant Biology, 54: 330–344 [下载]
  • Duan LX, Chen TL, Li M, Chen M, Zhou YQ, Cui GH, Zhao AH, Jia W, Huang LQ, Qi X*. 2012. Use of metabolomics approach to characterize Chinese medicinal material Huangqi. Molecular Plant, 5: 376-386 [下载]
  • Xue ZY, Duan LX, Liu D, Guo J, Ge S, Dicks J, Maille P, Osbourn A, Qi XQ*. 2012. Divergent evolution of oxidosqualene cyclases in plants. New Phytologist, 193: 1022–1038 [下载]
  • Wu XD,  Qi XQ*. 2010. Genes encoding hub and bottleneck enzymes of the Arabidopsis metabolic network preferentially retain homeologs through whole genome duplication. BMC evolutionary biology, 10: 145 [下载]
  • Wang LJ, Wang YJ, Wang Z, Marcel TC, Niks RE, Qi XQ*. 2010. The phenotypic expression of QTLs for partial resistance to barley leaf rust during plant development. Theoretical and Applied Genetics, 121: 857-864 [下载]
  • Mugford ST, Qi XQ, Bakht S, Hill L, Wegel E, Hughes RK, Papadopoulou K, Melton R, Philo M, Sainsbury F, Lomonossoff GP, Deb RA, Goss,RJM, Osbourn A*. 2009. A serine carboxypeptidase-like acyltransferase is required for synthesis of antimicrobial compounds and disease resistance in oats. Plant Cell, 21: 2473-2484 [下载]
  • Mylona P, Owatworakit A, Papadopoulou K, Jenner H, Qin B, Findlay K, Hill L, Qi XQ, Bakht S, Melton R, Osbourn A*. 2008. Sad3 and Sad4 are required for saponin biosynthesis and root development in oat. Plant Cell, 20: 201-212 [下载]
  • Zhao SZ, Qi XQ*. 2008. Signaling in plant disease resistance and symbiosis. Journal of Integrative Plant Biology, 50: 799-807 [下载]

  • Qi XQ, Bakht S, Qin B, Leggett M, Hemmings A, Mellon F, Eagles J, Werck- Reichhart D, Schaller H, Lesot A, Melton R, Osbourn A*. 2006. A different function for a member of an ancient and highly conserved cytochrome P450 family：From essential sterols to plant defense. Proc. Natl. Acad. Sci. USA, 103: 18848-18853

    [下载]
  • Bakht S, Qi XQ*. 2005. Ligation mediated rolling-circular amplification (RCA) based approaches to SNP detection. Expert Review of Molecular Diagnostics, 5: 111-116 [下载]
  • Qi XQ, Bakht S, Leggett M, Maxwell C, Melton R, Osbourn A*. 2004. Clustered genes for secondary metabolism in oat-Implications for the evolution of metabolic diversity in plants. Proc. Natl. Acad. Sci. USA, 101: 8233-8238 [下载]
  • Qi XQ, Pittaway TS, Lindup S, Liu H, Waterman E, Padi FK, Hash CT, Zhu J, Gale MD, Devos KM*. 2004. An integrated genetic map and a new set of SSR markers for pearl millet Pennisetum glaucum. Theoretical Applied Genetics, 109: 1485-1493 [下载]
  • Osbourn AE, Qi XQ, Townsend B, Qin B*. 2003. Dissecting plant secondary metabolism – constitutive chemical defenses in cereals. New Phytology, 159: 101-108 [下载]
  • Allouis S, Qi XQ, Lindup S, Gale MD, Devos KM*. 2001. Construction of a pearl millet BAC library using pBAC/SACB1，a positive selection vector．Theoretical and Applied Genetics, 102: 1200-1205 [下载]
  • Qi XQ, Lindup S, Pittaway TS, Allouis S, Gale MD, Devos KM*. 2001. Development of simple sequence repeat (SSR) markers from bacterial artificial chromosomes (BACs) without sub-cloning. BioTechniques, 31: 355-362 [下载]
  • Qi XQ, Bakht S, Devos KM, Gale MD, Osbourn A*. 2001. L-RCA (ligation-rolling circle amplification): a general method for genotyping of single nucleotide polymorphisms (SNPs). Nucleic Acids Research, 29: e116 [下载]
  • Haralampidis K, Bryan G, Qi XQ, Papadopoulou K, Bakht S, Melton R, Osbourn A*. 2001. A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots. Proc. Natl. Acad. Sci. USA, 98: 13431-13436 [下载]
  • Qi XQ, Stam P, Lindhout P*. 1996. Comparison and integration of four barley genetic maps. Genome, 39: 379-394 [下载]
  • Qi XQ, Lindhout P*. 1997. Development of AFLP markers in barley．Molecular Genetics and Genomics, 254: 330-336 [下载]
  • Schut JW, Qi XQ, Stam P*. 1997. Relationship between AFLP based genetic similarities and coefficients of co-ancestry in barley．Theoretical and Applied Genetics,95: 1161-1168 [下载]
  • Qi XQ, Stam P, Lindhout P*. 1998. Use of locus-specific AFLP markers to construct a high-density molecular map in barley. Theoretical and Applied Genetics, 96: 376-384 [下载]
  • Qi XQ, Niks RE, Stam P, Lindhout P*. 1998. Identification of QTLs for partial resistance to leaf rust (Puccinia hordei) in barley. Theoretical and Applied Genetics, 96: 1205-1215 [下载]
  • Qi XQ, Jiang GL, Chen WQ, Niks RE, Stam P, Lindhout P*. 1999. Isolate-specific QTLs for partial resistance to Puccinia hordei in barley. Theoretical and Applied Genetics, 99: 877-884 [下载]
  • Qi XQ, Fufa F, Sijtsma D, Niks RE, Lindhout P, Stam P*. 2000. The evidence for abundance of QTLs for partial resistance to Puccinia hordei on the barley genome. Molecular Breeding, 6: 1-9 [下载]
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